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Propionic Acidemia

Propionic Acidemia is a rare metabolic disorder characterized by deficiency of propionyl CoA carboxylase, an enzyme involved in the breakdown (catabolism) of the chemical "building blocks" (amino acids) of certain proteins. Symptoms most commonly become apparent during the first weeks of life and may include abnormally diminished muscle tone (hypotonia), poor feeding, vomiting, listlessness (lethargy), excessive loss of fluids from bodily tissues (dehydration), and episodes of uncontrolled electrical activity in the brain (seizures). Without appropriate treatment, coma and potentially life-threatening complications may result. In rare cases, the condition may become apparent later during infancy and may be associated with less severe symptoms and findings. Propionic Acidemia is inherited as an autosomal recessive trait

 

Remedy

Characteristics Symptoms

Patient Worse by

Patient Better by

Nux Vomica Rather thin, spare, quick, active, nervous, and irritable

Does a good deal of mental work; has mental strains and leads a sedentary life, found in prolonged office work, overstudy, and close application to business, with its cares and anxieties.

Seeks stimulants, coffee, wine, possibly in excess; or, again, he hopes to quiet his excitement, by indulging in the sedative effects of tobacco, if not really a victim, to the seductive drugs, like opium, etc

Takes preferably rich and stimulating food; wine and women play their part to make him forget the close application of the day

Pre-eminently a male remedy

Irritable, nervous system, hypersensitive and over-impressionable

Convulsions, with consciousness; worse, touch, moving

Zealous fiery temperament

Easily chilled, avoid open air, etc

Always seems to be out of tune; inharmonious spasmodic action

Sour taste, and nausea in the morning, after eating

Sour, bitter eructations

Nausea and vomiting, with much retching

Desire for stimulants

Loves fats and tolerates them well

Difficult belching of gas

Wants to vomit, but cannot

Frequent ineffectual desire for stools, or passing but small quantities at each attempt

Frequent calls to urinate; little and often

Easily excited desire

Menses too early, lasts too long; always irregular, blood black  with faint spells

Cannot sleep after 3 am until towards morning; awakes feeling wretchedly

Drowsy after meals, and in early evening

Dreams full of bustle and hurry

Morning

Mental exertion

After eating

Touch

Spices

Stimulants

Narcotics

Dry weather

Cold

From a nap, if allowed to finish it

In evening

While at rest

In damp, wet weather

Strong pressure

Conium Maculatum Difficult gait, trembling, sudden loss of strength while walking, painful stiffness of legs. etc

Debility

General feeling as if bruised by blows

Great debility in the morning in bed

Weakness of body and mind, trembling, and palpitation

Terrible nausea, acrid heartburn and acid eructations; worse on going to bed

Painful spasms of the stomach

Amelioration from eating and aggravation a few hours after meals; acidity and burning; painful spot the level of the sternum

Tremulous weakness after every stool

Much difficulty in voiding; it flows and stops again

Sexual desire increased; power decreased

Menses delayed and scanty; parts sensitive

Lying down

Turning or rising in bed

Celibacy

Before and during menses

From taking cold

Bodily or mental exertion

While fasting

In the dark

From letting limbs hang down

Motion and pressure

Digitalis Pulse is weak, irregular, intermittent, abnormally slow

Slow pulse in recumbent posture, but irregular and dicrotic on sitting up

Faint, as if dying

Bluish appearance of face

Prostration from slight exertion

Collapse

Sweet taste with constant ptyalism

Excessive nausea, not relieved by vomiting

Faintness, great weakness in stomach

Faintness and vomiting from motion

Discomfort, even after a small quantity of food, or from mere sight or smell

Tenderness of epigastrium

Copious salivation

White, chalk-like, ashy, pasty stools

Nightly emission, with great weakness of genitals after coitus

Starts from sleep in alarm that he is falling from a height

When sitting erect

After meals and music

When stomach is empty

In open air

Ferrum Metallicum Best adapted to young weakly persons, anæmic and chlorotic, with pseudo-plethora, who flush easily; cold extremities; over sensitiveness; worse after any active effort

Weakness from mere speaking or walking though looking strong

Pallor of skin, mucous membranes, face, alternating with flushes

Orgasms of blood to face, chest, head, lungs, etc. Irregular distribution of blood.

Muscles flabby and relaxed

Voracious appetite, or absolute loss of appetite

Loathing of sour things

Attempts to eat bring on diarrhœa

Spits up food by the mouthful

Eructations of food after eating, without nausea

Nausea and vomiting after eating

Vomiting immediately after eating

Vomiting after midnight

Intolerance of eggs

Distention and pressure in the stomach after eating

Heat and burning in stomach

Stool undigested, at night, while eating or drinking, painless

Urine involuntary; worse daytime

Menses remit a day or two, and then return;  too early, too profuse, last too long; pale, watery

While sweating

While sitting still

After cold washing and overheating

Midnight

Walking slowly about

After rising

Gelsemium General prostration

Dizziness, drowsiness, dullness, and trembling

Slow pulse, tired feeling, mental apathy

Muscular weakness

Complete relaxation and prostration. Lack of muscular co-ordination

General depression from heat of sun

Sensitive to a falling barometer; cold and dampness brings on many complaints

Children fear falling, grab nurse or crib

Sluggish circulation

Putrid taste and breath

No thirst

Urine profuse, clear, watery, with chilliness and tremulousness

Hysteric convulsions

Cannot get fully to sleep

Damp weather

Fog

Before a thunderstorm

Emotion, or excitement

Bad news

Tobacco-smoking

When thinking of his ailments

At 10 am

Bending forward

By profuse urination

Open air

Continued motion

Stimulants

Phosphorus Tall, slender persons, narrow chested, with thin, transparent skin, weakened by loss of animal fluids, with great nervous debility, emaciation, amative tendencies

Great susceptibility to external impressions, to light, sound, odors, touch, electrical changes, thunder-storms

Suddenness of symptoms, sudden prostration, faints, sweats, shooting pains, etc

Thirst for very cold water

Hunger soon after eating

Sour taste and sour eructations after every meal

Belching large quantities of wind, after eating

Throws up ingesta by the mouthfuls

Very fetid stools and flatus; long, narrow, hard, like a dog's; difficult to expel

Desire for stool on lying on, left side

Great weakness after stool

Lack of power; irresistible desire; involuntary emissions, with lascivious dreams

Menses too early and scanty-not profuse, but last too long

Leucorrhœa profuse, smarting, corrosive, instead of menses

Great drowsiness, especially after meals

Vivid dreams of fire; of hæmorrhage; lascivious dreams

Goes to sleep late and awakens weak

Short naps and frequent wakings

Touch

Physical or mental exertion

Twilight

Warm food or drink

Change of weather

From getting wet in hot weather

Evening

Lying on left or painful side

During a thunder-storm

Ascending stairs.

In dark

Lying on right side

Cold food

Cold

Open air

Washing with cold water

Sleep

Pulsatilla Pre-eminently a female remedy, especially for mild, gentle, yielding disposition

Sad, crying readily; weeps when talking; changeable, contradictory

Seeks the open air; always feels better there, even though he is chilly

Symptoms ever changing

Thirstless, peevish, and chilly

Great sensitiveness

Wants the head high; feels uncomfortable with only one pillow

Lies with hands above head

Greasy taste

Dry mouth, without thirst; wants it washed frequently; frequently licks the dry lips

Offensive odor from mouth

Food, especially bread, tastes bitter

Much sweet saliva

Alternations of taste, bitter, bilious, greasy, salty, foul

Loss of taste

Desire for tonics

Averse to fat food, warm food, and drink

Eructations; taste of food remains a long time; after ices, fruits, pasty

Bitter taste, diminished taste of all food

Flatulence

Dislikes butter

Heartburn

Thirstlessness

Vomiting of food eaten long before

Gnawing, hungry feeling

Water brash, with foul taste in the morning

No two stools alike

Two or three normal stools daily

Increased desire; worse when lying down

Tardy menses; too late, scanty, thick, dark, clotted, changeable, intermittent

Leucorrhœa acrid, burning, creamy

Wide awake in the evening; first sleep restless

Wakes languid, unrefreshed

Irresistible sleepiness in afternoon

From heat, rich fat food

After eating

Towards evening

Warm room

Lying on left or on painless side

When allowing feet to hang down

Open air

Motion

Cold applications

Cold food and drinks, though not thirsty

Mercurius Tremors everywhere

Weakness with ebullitions and tremblings from least exertion

Complaints increase with the sweat and rest; all associated with a great deal of weariness, prostration, and trembling

A human "thermometer"; sensitive to heat and cold

Breath, excretions and body smell foul

Tendency to formation of pus, which is thin, greenish, putrid; streaked with thin blood

Sweetish metallic taste

Salivary secretions greatly increased; bloody and viscid

Saliva fetid, coppery

Great thirst, with moist mouth

Putrid eructations

Intense thirst for cold drinks

Urine dark, scanty, bloody, albuminous

Menses profuse, with abdominal pains

Leucorrhœa excoriating, greenish and bloody; sensation of rawness in parts

General tendency to free perspiration, but patient is not relieved thereby.

At night

Wet, damp weather

Lying on right side

Perspiring

Warm room and warm bed

 
Natrum Muriaticum Great debility; most weakness felt in the morning in bed

Coldness

Great liability to take cold

Dry mucous membranes

Constrictive sensation throughout the body

Great weakness and weariness

Oversensitive to all sorts of influences

Hungry, yet loose flesh

Heartburn, with palpitation

Unquenchable thirst

Sweats while eating

Craving for salt

Aversion to bread, to anything slimy, like oysters, fats

Has to wait a long time for it to pass if others are present

Menses irregular; usually profuse

Leucorrhœa acrid, watery

Sleepy in forenoon

Nervous jerking during sleep

Dreams of robbers

Noise

Music

Warm room

Lying down

About 10 a m

At seashore

Mental exertion

Consolation

Heat

Talking

Open air

Cold bathing

Going without regular meals

Lying on right side

Pressure against back

Tight clothing

Sepia Weakness, yellow complexion, bearing-down sensation, especially in women, upon whose organism it has most pronounced effect

Upward tendency of its symptoms

Easy fainting

"Ball" sensation in inner parts

Acts best on brunettes

All pains are from below up.

Feels cold even in warm room

Taste salty, putrid

Everything tastes too salty

Nausea in morning before eating

Disposition to vomit after eating

Burning in pit of stomach

Longing for vinegar, acids, and pickles

Worse, after milk, especially when boiled

Acid dyspepsia with bloated abdomen, sour eructations

Loathes fat

Red, adhesive, sand in urine

Leucorrhœa yellow, greenish; with much itching

Forenoons and evenings

Washing

Laundry-work

Dampness

Left side

After sweat

Cold air

Before thunder-storm

By exercise

Pressure

Warmth of bed

Hot applications

Drawing limbs up

Cold bathing

After sleep

Aurum Metallicum Hopeless, despondent, and great desire to commit suicide; every opportunity is sought for self-destruction

Taste putrid or bitter

Appetite and thirst increased, with qualmishness

Burning at stomach and hot eructations

Urine turbid, like buttermilk, with thick sediment

Sleepless; sobs aloud in sleep

Frightful dreams

In cold weather

When getting cold

Many complaints come on only in winter

From sunset to sunrise

 
Baryta Carbonica Specially indicated in infancy and old age; this remedy brings aid to scrofulous children, especially if they are backward mentally and physically, are dwarfish, do not grow and develop, have scrofulous ophthalmia, swollen abdomen, take cold easily, and then always have swollen tonsil

Very sensitive to cold

Offensive foot-sweats

very weak and weary, must sit or lie down or lean on something

Very averse to meeting strangers

Water brash, hiccough, and eructation, which relieves pressure as of a stone

Hungry, but refuses food

Pain and weight immediately after a meal, with epigastric tenderness

Habitual colic, with hunger, but food is refused

Constipation, with hard, knotty stools

Diminished desire and premature impotence

Menses scanty

Talking in sleep; awakens frequently; feels too hot

Twitching during sleep

While thinking of symptoms

From washing

Lying on painful side

After warm food

Walking in open air
Zincum Metallicum Defective vitality

 

Twitchings

Convulsions, with pale face and no heat.

Trembling, convulsive twitching and fidgety feet

Bloody taste

Hiccough, nausea, vomiting of bitter mucus

Burning in stomach, heartburn from sweet things

Cannot stand smallest quantity of wine

Ravenous hunger about 11 am

Great greediness when eating; cannot eat fast enough

Atonic dyspepsia, feeling as if stomach were collapsed

Griping after eating

Can only void urine when sitting bent backwards

Involuntary urination when walking, coughing or sneezing

Erections violent

Menses too late, suppressed; menses flow more at night

Cries out during sleep; body jerks; wakes frightened, stared

Nervous motion of feet when asleep

Loud screaming out at night in sleep without being aware of it

At menstrual period

From touch

Between 5 to 7 pm

After dinner

From wine

While eating

Discharges

Appearance of eruptions

Ruta All parts of the body are painful, as if bruised

Feeling of intense lassitude, weakness and despair

Gastralgia of aching, gnawing character

Constant urging to urinate, feels bladder full

Lying down

From cold, wet weather

 
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